When one looks at global morbidity and mortality rates over the last century, three major innovations stand out as the biggest drivers in reducing  the impact of infectious disease: establishment of public health/sanitation authorities, antibiotics, and vaccination [Fig. 1].  Fig 1. Deaths per 100k Population due to Infectious Diseases, 1900-2000 All three of these pillars are now under threat. Public health departments have been chronically underfunded for decades, and outside of major emergencies public health is poorly prioritized [1]. Antibiotic resistance is proliferate and we are now seeing microorganisms that are effectively immune to all known antimicrobial treatments [2]. Vaccines, long held to be safe and effective prophylaxis, are increasingly targets of mistrust and misinformation, especially in the wake of the COVID-19 pandemic, and vaccination rates have declined in recent years, due to a number of reasons. There is no question that vaccines have saved lives in t...